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N-Acetyl-D-Glucosamine is white crystalline powder, while it's Molecular Formula is C8H15NO6. N-Acetyl-D-glucosamine is used in the identification and characterization of N-acetyl-beta-D-hexoaminidase. It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.
The CAS number of N-Acetyl-D-Glucosamine is 7512-17-6.
More information of N-Acetyl-D-Glucosamine 7512-17-6 are:
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Synonyms |
2-Acetamido-D-glucose;N-acetyl-β-D-glucosamine;2-Acetamido-2-deoxy-D-glucose;N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide;N-acetyl D-Glucosamine;D-Glucose, 2-(acetylamino)-2-deoxy-; |
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CAS Number |
7512-17-6 |
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Molecular Formula |
C8H15NO6 |
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Molecular Weight |
221.21 |
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Density |
1.423 g/cm3 |
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Melting Point |
211 °C (dec.)(lit.) |
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Boiling Point |
636.4 °C at 760 mmHg |
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Flash Point |
338.7 °C |
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HS CODE |
2932.99 |
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PSA |
127.09000 |
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LogP |
-2.84410 |
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Pka |
13.04±0.20(Predicted) |
N-Acetyl-D-Glucosamine is the N-acetyl derivative of glucosamine.Chemically it is an amide between glucosamine and acetic acid. A single N-acetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins -O-GlcNAc, is an ubiquitous post-translational protein modification. O-GlcNAc modified proteins are involved in sensing the nutrient status of the surrounding cellular environment and adjusting the activity of cellular proteins accordingly. O-GlcNAc regulates cellular responses to hormones such as insulin, initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription. In humans, it exists in skin, cartilage and blood vessel as a component of hyaluronic acid, and bone tissue, cornea and aorta as a component of keratan sulfate. N-Acetyl-D-glucosamine (D-GlcNAc) is a derivitized glucose monomer found in polymers of bacterial cell walls, chitin, hyaluronic acids and various glycans. It is also synthesized in the glycosylation pathway as uridine diphosphate (UDP-GlcNAc), which can then be released following degradation of glycosylated proteins.D-GlcNAc is used to identify, differentiate and characterize N-acetyl-β-D-hexoaminidase(s). It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.
InChI:InChI=1/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)
Articles related to N-Acetyl-D-Glucosamine:
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Article |
Source |
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Synthesis and anti-acetylcholinesterase activities of novel glycosyl coumarylthiazole derivatives |
Cao, Lian-Gong,Cao, Zhi-Ling,Jiang, Kai-Jun,Liu, Shu-Hao,Liu, Wei-Wei,Lu, Xing,Shao, Zhong-Bai,Shi, Da-Hua,Wang, Lei,Wang, You-Xian , p. 359 - 364 (2020/12/28) |
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Biochemical Characterization and Structural Analysis of a β- N-Acetylglucosaminidase from Paenibacillus barengoltzii for Efficient Production of N-Acetyl- d -glucosamine |
Liu, Yihao,Jiang, Zhengqiang,Ma, Junwen,Ma, Shuai,Yan, Qiaojuan,Yang, Shaoqing , p. 5648 - 5657 (2020/06/03) |
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