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Various bleedings caused by acute or chronic, localized or systemic primary hyperfibrinolysis; secondary hyperfibrinolytic state caused by disseminated intravascular coagulation. Generally do not use this product before heparinization. Trauma or surgical bleeding in tissue and organs with abundant plasminogen activators such as prostate, urethra, lung, brain, uterus, adrenal glands, and thyroid. An antagonist of tissue plasminogen activator (t-PA), streptokinase, and urokinase. Fibrinolytic hemorrhage caused by artificial abortion, early placental detachment, stillbirth and amniotic fluid embolism; and increased menorrhagia caused by pathological intrauterine fibrinolysis. Cerebral neuropathy mild bleeding, such as subarachnoid hemorrhage and intracranial aneurysm hemorrhage, the effect of Amstat in this condition is better than that of other anti-fibrinolytic agents. Special attention must be paid to the risk of cerebral edema or cerebral infarction. ?For severe patients with surgical indications, this product can only be used as an adjuvant drug. For the treatment of hereditary angioneurotic edema, it can reduce the number and severity of episodes. Used in patients with hemophilia for their active hemorrhage in combination with others drug. Hemophilia patients with factor VIII or factor IX deficiency in their tooth extraction or oral surgery in case of operating bleeding.
Fibrinolysis, the cleavage of fibrin by plasmin, is a normal step in the dissolution of fibrin clots after wound repair. Tranexamic acid is an inhibitor of fibrinolysis that blocks the interaction of plasmin with fibrin (IC50 = 3.1 μM). It is a lysine mimetic that binds the lysine binding site in plasmin. Antifibrinolytic agents have value when fibrinolytic activity is abnormally high or when coagulation is impaired.
4-aminomethyl-cyclohexanecarboxylic acid
| Conditions | Yield |
|---|---|
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C12H17NO5
maleic anhydride
trans-4-aminomethyl-cyclohexyl-carboxylic acid
| Conditions | Yield |
|---|---|
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With
hydrogenchloride;
In
water;
for 1h;
Kinetics;
|
The CAS number of Amstat is 1197-18-8.
More information of Amstat 1197-18-8 are:
|
CAS Number |
1197-18-8 |
|
Density |
1.096 g/cm3 |
|
Melting Point |
300 °C |
|
Boiling Point |
300.201 °C at 760 mmHg |
|
Flash Point |
135.357 °C |
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Vapor Pressure |
0mmHg at 25°C |
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Refractive Index |
1.4186 (estimate) |
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HS CODE |
29224999 |
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PSA |
63.32000 |
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LogP |
1.53640 |
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Pka |
pKa 4.3 (Uncertain);10.6 (Uncertain) |
Synonyms for Amstat 1197-18-8:trans-4-Aminomethylcyclohexane-1-carboxylic acid;trans-4-(Aminomethyl)cyclohexanecarboxylic acid;trans-1-(Aminomethyl)cyclohexane-4-carboxylic acid;Acido tranexamico [INN-Spanish];4-(aminomethyl)cyclohexane-1-carboxylic acid;Cyclohexanecarboxylic acid, 4- (aminomethyl)-, trans-;Frenolyse;Tamcha;Cyclohexanecarboxylic acid,4-(aminomethyl)-,trans-;Trans-4-(Aminomethyl)cyclohexane-1-carboxylic acid;trans-1-Aminomethylcyclohexane-4-carboxylic acid;Tranex;trans-4-(Aminomethyl)cyclohexanecarboxylic acid; Tranexamic Acid;Tranesamic acid;CYCLO CAPRON;Transamin;Tranexan;Rikavarin-S;Rikavarin (TN);4-(Aminomethyl)cyclohexanecarboxylic acid;Hexatron;Trans-p-(Aminomethyl)cyclohexanecarboxylic acid;Amikapron;Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-;Ugurol;trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid;
The chemical formula of Amstat is C8H15NO2 which containing 8 Carbon atoms,15 Hydrogen atoms,1 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight of Amstat is 157.213.
Amstat is a pharmaceutical secondary standard used for quality control in pharmaceutical laboratories and manufacturing. It serves as a convenient and cost-effective alternative to the preparation of in-house working standards. Amstat is a white or almost white, crystalline powder.
InChI:InChI=1/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-
Relevant articles related to Amstat:
|
Article |
Source |
|
READY-TO-USE TRANEXAMIC ACID INTRAVENOUS SOLUTION |
- , (2020/04/09) |
|
Design, synthesis and in vitro kinetic study of tranexamic acid prodrugs for the treatment of bleeding conditions |
Karaman, Rafik,Ghareeb, Hiba,Dajani, Khuloud Kamal,Scrano, Laura,Hallak, Hussein,Abu-Lafi, Saleh,Mecca, Gennaro,Bufo, Sabino A. , p. 615 - 635 (2013/09/02) |
P&K INTERNATIONAL PTE. LTD. is a quality supplier of Amstat. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Amstat 1197-18-8.
